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(2003) Detoxification of electrophilic compounds by glutathione S-transferase catalysis: determinanats of individual response to chemical carcinogens and chemotherapeutic drugs

Use of antioxidants may therefore be a vital factor in sperm survival and function before, during and after cryopreservation

We identified notable metabolites that increased or decreased with age (Fig 1A)

The N-terminal region of native IGF-1 is directly involved in IGFBP binding: the related analog des(1-3)IGF-I simply deletes the first three residues (Gly-Pro-Glu), and this alone sharply lowers IGFBP affinity while leaving receptor binding largely intact

This disruption causes a redox imbalance, leading to membrane lipid peroxidation, reactive oxygen species (ROS) accumulation, and ultimately, iron-dependent oxidative cell death [3]