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doi: 10.1002/advs.202409837

Rather than activating the growth hormone receptor, AOD 9604 functions as a pathway-specific modulator of lipid metabolism, enabling investigation of lipolysis and energy regulation in experimental systems without engagement of IGF-1mediated endocrine signaling

Franklin, C

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Individuals with GH resistance, as seen in Laron syndrome, a rare genetic condition resulting from an inactivating mutation in the GHR, are protected from cancer and diabetes