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[7] [9] Patients with a history of oxalate nephrolithiasis (kidney stones) or hyperoxaluria should avoid high-dose vitamin C administration, as ascorbic acid is metabolized to oxalate, which may precipitate stone formation or exacerbate renal impairment

11 AvolioE.OlivitoI.RosinaE.RomanoL.AngeloneT.De BartoloA.et al (2022)

Participants experienced as much as 24 percent body weight loss at 48 weeks at higher doses

Analysis of genetic polymorphisms related to thrombosis and other risk factors in patients with retinal vein occlusion

To sum up, these imaging techniques have huge potential in noninvasively visualizing RONS in macrophages to reveal diseases progression