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induced the release of prostaglandins E2 (PGE2) and NO by upregulating the gene expression of COX-2 and iNOS , respectively 79

Vitamin A is essential for the developing CNS where it affects neurogenesis and neuronal patterning, but keeps playing an important role in the adult brain by regulating neuroplasticity in cerebral structures [100]

Therefore, an antioxidant substance with strong ROS scavenging capabilities represents a potential candidate for treating UVB-induced skin damage or photoaging 14

Consequently, any skin irritation with basement membrane disruption can deteriorate melasma condition and also induce persistence or recurrence type of the disease (Kwon et al., 2016)

These clinical trials, although very important to determine the effectiveness of the strain and the potential harmful effects, are particularly expensive, time-consuming and difficult to implement (8)