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Nat Rev Endocrinol 16(3):165176

Simultaneous estimation of quercetin and silymarin: method development and validation

Interestingly, already the smell of hidden food stimuli activates AgRP and POMC neurons in the hypothalamus 3,4 suggesting a strong influence of olfactory inputs on hypothalamic regulation of energy homeostasis

Remaining challenges include variability of natural sources, limited pharmacokinetic and toxicological data, and hurdles in scale-up and standardization