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When the Cu content in hepatocytes increases, ATP7B relocates to the bile duct membrane of the hepatocytes and excretes Cu from the biliary tract along with the bile through transmembrane transport

Research published in JCI Insight describes tirzepatide as an "imbalanced and biased" dual agonist, meaning it shows equal affinity for the GIP receptor compared to native GIP but approximately 5-fold weaker affinity for the GLP-1 receptor compared to native GLP-1

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