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demonstrated that MOTS-c therapy prevented vascular calcification in Vitamin D3 plus nicotine-treated rats (VDN) by activating AMPK signalling, and reversing the overexpression of Angiotensin 1(AT-1) and Endothelin B (ET-B) receptors induced by VDN [78,79]

61 demonstrated that NR supplementation altered the gut microbiome in mice and demonstrated that the gut microbiome change was able to impact weight gain in mice fed a high-fat diet

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