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Mol Cell 55:578591 Kallajoki M, Harborth J, Weber K, Osborn M (1993) Microinjection of a monoclonal antibody against SPN antigen, now identified by peptide sequences as the NuMA protein, induces micronuclei in PtK2 cells

Treatment plans are continuously evaluated and adjusted based on patient response and tolerance

Very high doses (several grams daily) have been reported to affect INR in isolated cases Folic acid and B vitamins : Generally safe with warfarin at standard supplemental doses Minerals : No clinically significant interaction expected at typical supplemental doses of calcium, magnesium, and zinc St John's wort : Avoid completely with warfarin and DOACs as it can significantly reduce their effectiveness For patients taking direct oral anticoagulants (DOACs) , the situation differs significantly

Nat Rev Mol Cell Biol (2020) 21:36383

Jagust, W