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PubMed , Morita, Shin-ya

Brain imaging studies have shown structural and functional alterations in depression, particularly the decreased volume of the hippocampus and the subgenual and anterior cingulate cortex of the prefrontal cortex (134, 135)

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4.4 DAMP release and inflammatory amplification Ferroptotic cells release DAMPs that act as alarmins, activating innate and adaptive immunity and perpetuating inflammatory cycles