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While it was long assumed that patients simply suffered from systemic glutathione depletion, a landmark 2025 study published in the Proceedings of the National Academy of Sciences (PNAS) uncovered a more complex reality

Across multiple independent cohorts (Table 1), UC is consistently associated with increased relative abundance of Proteobacteriaparticularly the Enterobacteriaceae alongside reduced levels of health-associated groups such as Bifidobacterium , Lachnospiraceae, and Verrucomicrobia (e.g., Akkermansia

Biochim Biophys Acta Mol Basis Dis (2021) 1867:166114

J Drugs Dermatol 2013;12(9 Suppl):s123-s127