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substitution with other residues dramatically reduces copper-binding affinity and alters the complex's properties

Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein HC, Miller ME, et al

Kadry H, Noorani B, Cucullo L

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In vitro work using LED photoirradiation of fibroblast cultures demonstrated that copper peptide supplementation significantly increased collagen synthesis compared to untreated controls, suggesting a synergistic interaction between GHK-Cu and cellular bioenergetic pathways