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However, this metaanalysis did not consider the potential link with metformin use

Healthcare research depends on this data to analyze trends and improve patient safety

Specifically, one study found that when leaky Madin-Darby canine kidney type II cells were treated with LA, tight junction proteins, including occludin and claudin-3, had less intracellular distribution (and concurrently more membrane expression), whereas actin was more associated with intercellular junctions (25)