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Management of congenital ichthyoses: european guidelines of care, part one

Not until it gets uncomfortable

This includes changes in functional activity in specific brain regions, such as reductions in the prefrontal cortex, caudate nucleus, and fronto-striatal regions when doing cognitive tasks (Sasikumar and Strafella, 2020)

Galy B, Ferring D, Benesova M, Benes V, Hentze MW (2004) Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo