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This activation is mediated by the binding of phosphatidylinositol (3,4,5)-trisphosphate (Ptdlns(3,4,5) P 3 ) to the Pleckstrin homology (PH) domain of mSIN1, which relieves its autoinhibition and enables mTORC2 to phosphorylate and activate AKT (Kim and Guan, 2019

PMID 30653247

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This is what GABA does it causes ions to move, changing the voltage potential within the cell