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Proper nasal technique proves absolutely critical - head tilted slightly forward (not back), gentle breathing (not hard sniffing), alternating nostrils with 1-2 minute intervals, and avoiding immediate swallowing determines success versus complete failure

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Claims data have inherent limitations: 1) There may be coding errors and missing data 2) Lack of data on reason for discontinuation 3) ICD-10 codes do not identify patients by MS subtypes

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GHK-Cu may promote mucosal healing and enhance tight junction protein expression by regulating the SIRT1/STAT3 pathway