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Interactions between ferroptosis-related signaling pathways in cancer drug resistance Notably, interactions among ferroptosis-related pathways, especially GPX4, NRF2, and iron metabolism regulators, are pivotal in cancer drug resistance

DJ-1 exposed to oxidative stress undergoes oxidation of Cysteine106 and translocates from cytoplasm to mitochondria or to the nucleus (Junn et al

I.FalconR

So far, Sil1 has been recognized as the gene responsible for about half of the MSS cases, while the trigger for the remaining ones is still unknown

To confirm this hypothesis, we generated a novel 3x Flag-Bnip3 knock-in mouse model using CRISPR/Cas 9-based technology ( Flag-Bnip3 ki/ki , Flag-Bnip3 ki/+ , Flag-Bnip3 /