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Nature 562 , 526531 (2018)

70 BCKDK inhibitors are also effective in attenuating insulin resistance in mouse models of obesity, and the development of a new generation of more powerful BCKDK inhibitors is important for diseases that require inhibition of BCAA catabolism

Primarily, it's used in weight loss and thermogenic supplements to help the body burn more calories and support a higher metabolic rate, working by transforming energy-storing white fat cells into heat-generating brown fat cells