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This is partly driven by the observation that mucosal irritants in gastroduodenal contents are secreted in response to food intake and can be modulated by altering the diets nutritional composition (Figure 1) (Reference Newberry and Lynch13)

In long-term evolution, human UA kinase factors and a series of promoter gene mutations have caused humans to have higher UA levels than other mammals (Figure 1) (Liangshan Mu et al., 2018

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The Nitrate-Nitrite-Nitric Oxide Pathway on Healthy Ageing: A Review of Pre-clinical and Clinical Data on the Impact of Dietary Nitrate in the Elderly

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