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ZIP synergy scores less than -10 were considered antagonistic, scores from -10 to 10 were considered additive and scores greater than 10 were considered strong synergistic (PMID: 35580060)

Thus, OS in DM represents a paradigm of metabolic memory, where initial oxidative damage perpetuates dysfunction long after glycemic control is achieved, underscoring the need for early redox-targeted therapies

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doi: 10.1016/j.prp.2016.02.001 166 UminoHHasegawaKMinakuchiHMuraokaHKawaguchiTKandaTet al

P-glycoprotein (P-gp) plays a role in ACs efflux transport, though some studies report low permeability without significant efflux activity (Gao et al