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An increase in oxidative stress and cell damage causes an increased usage of glutathione and decreased levels

[DOI] [PMC free article] [PubMed] [Google Scholar] 123.Stockli J, Zadoorian A, Cooke KC, Deshpande V, Yau B, Herrmann G, et al

The recipient mice were treated with tamoxifen, which leads to the activation of Cre recombinase activity and subsequent deletion of Gclc specifically in the implanted tumours (Fig