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In other diseases, inhibition of ACSL4 to reduce lipid peroxides and ferroptosis is a possible therapeutic strategy, but there is currently no similar study in preclinical studies of Friedreichs Ataxia

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Indeed, the association of doxorubicin with bioenergetic toxicity is well stated in the literature 32,33,34

For example, melatonin dampens the promoting effect of iron overload on the process of osteogenic differentiation dysfunction and senescence by inhibiting the processes of ROS generation and p53/ERK/p38 activation (Yang et al., 2017)

Ferroptosis in aortic dissection Vascular disease is a complex subtype of cardiovascular disease, attributed to multiple factors such as genetic variation, environmental influences, and lifestyle habits