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Activation of HIF-1 C-terminal transactivation domain promotes tubulointerstitial fibrosis through hexokinase 2-mediated metabolic reprogramming

In addition, SARS-CoV-2 infection leads to the release of pro-angiogenic factors, such as vascular endothelial growth factor A (VEGF-A) (23)

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For this reason, patients with a history of immunoglobulin (Ig) Emediated (allergic or anaphylactic) reaction to a sulfonamide antibiotic can receive nonantimicrobial sulfonamides such as celecoxib, chlorthiazide, furosemide, and others without elevated risk of an IgE-mediated reaction compared with the general population