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Hypoxia-sensitive pathways in intestinal inflammation

A large quantity (85~90%) of CD38 high NK cells are killed

OSR / NBMI by Boyd Haley Boyd Haley developed a compound over 20 years ago which may be superior to all other chelators, including DMSA, DMPS, ALA, or EDTA

Aborted LR3 clinical studies in oncology (late 1990s) highlighted the complexity of IGF-1R targeting: mitogenic potential on mammary and prostate tumor lines, requiring abandonment of development in favor of IGF-1R antagonists (monoclonal antibodies such as figitumumab, ganitumab, dalotuzumab) which also encountered phase III failures but enriched understanding of the IGF axis role in carcinogenesis

This consideration is based on the fact that independent regulation of gliT may have enabled acquisition of functionality beyond a role in gliotoxin biosynthesis or auto-protection