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The upregulation of Bax and suppression of Bcl-2 in the DEX group indicate a shift toward pro-apoptotic signalling

doi: 10.1038/ncomms12276 108 BurnhamELHalkarRBurksMMossM

This can lead to pancreatitis and other metabolic issues if left unresolved

Results The isolated pHAT domains of TaOGA and hOGA form homodimers Although hOGA is a multi-domain protein including a C-terminal pHAT domain, structural studies of the full-length enzyme have been hampered by the presence of several predicted large disordered regions (Fig