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Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase

The extensive preclinical research foundation, favorable preclinical safety profile, and preliminary human experience suggest BPC-157 warrants continued investigation as a potential therapeutic agent for tissue repair and regeneration

10.1007/BF01805554

At the same time, an in vivo experiment showed that the repair effect in the co-culture group was significantly better than that in the monoculture BMSC group [106]

Compared with ADCs, PDCs exhibit better tumor penetration because of their small molecular weight, lower systemic exposure (owing to rapid clearance from the body), lower risk of immunogenicity and liver damage, and easier and cheaper production methods