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Qualitative images at higher magnifications were acquired using a 63X Plan Apochromat (NA = 1.40) oil immersion objective (pixel = 0.05 m)

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The core pathological progression of Alzheimer's disease revolves around the abnormal aggregation of -amyloid into toxic oligomers and fibrillar plaques, as well as the hyperphosphorylation of tau protein leading to neurofibrillary tangles

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When surgery is successful, patients regain much of the function of their hand