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This is supported by the fact that the administration of recombinant IGF-1 abrogates pro-inflammatory cytokine-induced net protein loss and enhances peripheral glucose clearance in lambs [53], and that muscular protein synthesis is correlated with IGF-1 in immunity-challenged animals [54]

Wang T, Sternes PR, Guo X-K, Zhao H, Xu C, Xu H (2024) Autoimmune diseases exhibit shared alterations in the gut microbiota

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However, growing evidence indicates that alternative metabolic routes such as malic enzyme 1 (ME1), isocitrate dehydrogenases (IDH1 and IDH2), and the folate cycle also significantly contribute to NADPH production, particularly under stress conditions or during metabolic reprogramming [43]

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