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Clinical studies further support these findings, reporting mean maximum plasma concentrations (Cmax) of AS-IV at 2.12, 3.59, 3.71, and 5.17 g/mL following single doses of 200, 300, 400, and 500 mL of astragaloside injection (AI), respectively (Xu et al., 2013)

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If testosterone therapy is started in a patient on a blood thinner, more frequent monitoring of coagulation (e.g., INR) and dose adjustments of the anticoagulant may be necessary

The metabolic product of PAHs, particularly BPDE, not only forms covalent adducts with DNA, resulting in genomic instability, but also regulates the expression of oncogenes and tumor suppressor genes through epigenetic mechanisms (Li et al., 2007