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Among these, hexahydroquinolines (HHQs) have emerged as particularly promising scaffolds, combining the pharmacophoric features of quinolines with enhanced conformational flexibility and improved druglike properties (Sridharan et al., 2011)

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Although the analysis by Travison et al did reveal significant age-related increases in adiposity and medication use and a welcome decline in smoking, the age-matched decline in testosterone concentrations persisted even after adjusting for these variables, Shalender Bhasin, MD, of the section of endocrinology, diabetes, and nutrition, Boston University School of Medicine, wrote in an accompanying editorial

The mass and NMR spectra were analyzed using MassHunter 10.0 (Agilent) and MestReNova-9.0.1 (Mestrelab Research), respectively