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PLoS One 7 , e36610 (2012)

FDA also identified potential immunogenicity concerns associated with peptide aggregation and related impurities

Yamaoka H, Asato H, Ogasawara T, Nishizawa S, Takahashi T, Nakatsuka T, Koshima I, Nakamura K, Kawaguchi H, Chung UI, Takato T, Hoshi K

However, as it was necessary to estimate a unique model parameter set for each individual in order to infer the glucose curve, this method is computationally much more heavy than cubic splining