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Contraindications include active or recent cancer, uncontrolled diabetes, severe diabetic retinopathy, and pregnancy

The 2006 Ionescu paper documented that pulsatile GH secretion persisted under continuous CJC-1295 stimulation, an unexpected finding that has shaped subsequent GH-axis research interpretation (PMID 17018654)

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These adjustments should always be made with guidance from a medical provider

Injecting more frequently than every 3 hours produces diminishing returns because the somatotroph cells have not had time to resynthesize and store growth hormone for the next pulse