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HYGIENE A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS A61P39/00General protective or antinoxious agents A61P39/06Free radical scavengers or antioxidants AHUMAN NECESSITIES A23FOODS OR FOODSTUFFS

Elevated fumarate has been implicated in metabolic and respiratory diseases, such as airway obstruction and diabetes [83, 84]

This is the starting material for important substances such as taurine and the central detoxifier, glutathione

Despite the results observed during the seasons, after exposure of the oocytes to temperatures of 38.5 C or above, the oocyte may not be able to counteract this damage, as it may not have an active defense system, resulting in irreversible damage that leads to an increased percentage of dead cells and DNA damage

Most common adverse events: nausea, headache, dizziness, constipation