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Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities

These limitations dont invalidate the positive safety findings but do suggest that comprehensive medical supervision remains appropriate for anyone using AOD-9604, particularly for off-label applications or extended treatment periods

Smoking aggravates most medical complications of obesity, and cessation is often concurrently recommended

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A recent study shows inflammation markers like C-Reactive Protein (hs-CRP) boost weight gain