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The most common side effects appear to be related to the method of administration, which is typically intramuscular or subcutaneous injection

Overall, this trial was designed to precisely determine the dose-response relationship, efficacy, and safety of Cagrilintide compared with placebo and liraglutide, while employing advanced statistical methods to ensure reliable interpretation of treatment effects under both ideal and real-world adherence conditions

The findings point to ID1 and ID3 as promising targets for new treatments and highlight multiple potential paths forward, including drug development and targeted delivery strategies

However, no significant change in p-JNK protein level was observed in HUVECs (Figure 6)