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is supported by a Wellcome Career Development Award (#225263/Z/22/Z)

Key challenges in oral delivery of cyclic peptides The poor oral bioavailability of cyclic peptides stems from numerous interdependent factors, including physicochemical constraints, gastrointestinal (GI) tract biology, enzymatic degradation, active efflux, and first-pass metabolism, which result in low and variable oral absorption: 1

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In a randomized controlled trial, levocarnitine significantly enhanced sperm motility, morphology, and concentration when compared to coenzyme Q10 and vitamin E (164)