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A hepatic immune response will be triggered by the interaction of PAMPs (e.g., LPS and bacterial RNA) with pathogen recognition receptors such as Toll-like receptor (TLR)4 on hepatic Kuppfer cells, the resident macrophages in the liver sinusoids (130)

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In February, the US Food and Drug Administration asked the companies to submit a request for emergency use authorization based on the two-dose data, but then postponed a meeting of the agency's vaccine advisory board so the third-dose data could be considered