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While CPT1A inhibitors (etomoxir, perhexiline) show preclinical efficacy in reducing infarct volumes and improving motor recovery in rodents by attenuating NLRP3 inflammasome activation and IL-1 release [212], translation to humans faces significant hurdles

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doi: 10.1016/j.jconrel.2014.02.002 204 PflanznerT.KuhlmannC

This approach may reveal new biomarkers that can be used to diagnose, prognosticate, or develop targeted treatments for glaucoma

Glutaredoxin from bacterial and mammalian species share 450 % and 6176 % identity with Grx1 and Grx2, respectively