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Glutamate is essential for synaptic functionality within the brain and is also identified as a precursor for GABA (Roberts and Frankel, 1950)

For instance, the D/L enantiomers of 2-microglobulin K3 form independent fibrils without cross-reactivity, whereas the D/L mixture of L4K8L4 undergoes a complete assembly pathway transformation, resulting in non-fibrous spherical aggregates