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Structural assignments were further supported by J-resolved and TOCSY spectra and validated using carbon chemical shifts from HSQC spectra

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Furthermore, a significant study involving over 4,000 individuals undergoing coronary angiography revealed that those with TMAO levels in the highest quartile faced a 2.5 times greater risk of experiencing myocardial infarction, stroke, or vascular death within a span of three years (Tang et al., 2013)