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10.1038/s41388-020-1355-8 325 ShimbaS.OgawaT.HitosugiS.IchihashiY.NakadairaY.KobayashiM.et al (2011)

As a macromolecular molecule, APS are insoluble in water, have a low oral absorption rate and a low bioavailability, and are quickly affected by stomach acid and other variables, resulting in a highly limited therapeutic effectiveness

If not quickly treated, these symptoms can lead to anaphylactic shock and death

In an ongoing Phase 2a study assessing IDR as lead-in (24 weeks) followed by 12 or 24 weeks of IFN additional IDR doses in HBeAg-negative CHB subjects virally suppressed on nucleos(t)ide analog (NA) therapy (AB-729-201, IM-PROVE I), soluble immune biomarkers were profiled and association with HBsAg response assessed

Future research should explore the bidirectional crosstalk between sex hormones and mitochondrial signaling, paving the way for more precise and safer therapeutic strategies tailored to individual pathophysiological profiles