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As expected, salsolinol formation was catalase-dependent, as lowering the units/mL of the enzyme also reduced salsolinol abundance (Supplementary Fig

With regards to their use as penetration enhancers in some embodiments, chelating agents have the added advantage of also serving as DNase inhibitors, as most characterized DNA nucleases require a divalent metal ion for catalysis and are thus inhibited by chelating agents (Jarrett, J

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second, it allows drug action at a specific site primarily aimed at reducing adverse drug reactions (e.g., antibodydrug conjugates)

Mavigner M, Cazabat M, Dubois M, LFaqihi FE, Requena M, Pasquier C, Klopp P, Amar J, Alric L, Barange K, Vinel JP, Marchou B, Massip P, Izopet J, Delobel P