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Solid debris was pelleted by centrifugation, and the supernatants were transferred to new vials for analysis by UHPLC-qTOF-MS

Direct induction of uric acid degradation using enzymes such as the recombinant PEGylated uricase pegloticase is an alternative approach to hyperuricemia that targets excess body urate burden irrespective of its etiology and is particularly useful for severe tophaceous gout ( Difficult Gout and Hyperuricemia )

Activated microglias are involved in translocation of redox-sensitive nuclear factor kappa-B to the nuclear environment that subsequently causes TH enzyme loss (Sawada et al., 2006)

Mitochondrial permeability transition pore in ASD Under physiological conditions, the IMM is impermeable to most molecules and ions

Rodgers & King, 2000)