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isoproterenol's short duration of action & bothersome side effects (tremor, tachycardia) reduced its popularity once inhaled formulations of selective beta-2 agonists became available isoproterenol continues to carry an FDA-approved indication for treatment of bronchospasm during anesthesia Subcutaneous SABA Formulations Formulations for subcutaneous injection are useful for treating severe asthma requiring emergency treatment when either aerosolized therapy is not available, or has been ineffective (e.g

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In AML, overexpression of EZH2 results in the downregulation of tumor suppressor genes, such as p16INK4a and p53 , which promotes leukemia cell proliferation and increases resistance to chemotherapy (Tsai et al., 2022)