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Subcutaneous delivery suits both peptides: it gives a smooth absorption curve that fits the once-daily, pulse-timed design, and it keeps the injection itself low-volume at roughly a tenth of a millilitre

Insulin-like growth factor-I and -II levels are associated with the progression of nonalcoholic fatty liver disease in obese children

Furthermore, dextran sulfate sodium or trinitrobenzenesulfonic acid-mediated colitis in mice both demonstrated a mitigation of disease when treated with a TL1A antagonist antibody, manifested as reduction in weight loss, mortality, and histologic score (6, 9)

2022 Apr 11;13(1):159

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