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Since the impact of diabetes on brain metabolic pathways may precede synaptic degeneration, neuronal loss and tissue atrophy, the ability of detecting such brain metabolic alterations early in the neurodegenerative process will allow for effective pharmacological and/or behavioural interventions

Distant metastases form monophyletic groups and have reduced clonality compared to LN metastases, suggesting different evolutionary mechanisms between LN metastases and distant metastases (154)

In addition to TET enzymes, VitC enhances the activity of Jumonji C (JmjC) domain-containing histone demethylases (JHDM) and thereby hinders the aberrant self-renewal of hematopoietic stem cells [3]

Ichimura et al., 2000)

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