glutathione function in drug metabolism Glutathione-Mediated Conjugation of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Detoxification and Bioactivation Glutathione-Mediated Conjugation of Anticancer Drugs:

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The review was conducted under the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, where applicable, to ensure transparency and reproducibility

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112 Chronic inflammation in the TME, which is mediated by cytokines such as IL-6, IL-8, and TNF-, can drive epigenetic and transcriptional reprogramming via the NF-B, JAK/STAT, and COX-2 pathways

While glutathione supports cellular antioxidant defense theoretically, no published randomized trials confirm benefit in this specific population