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There can be large inter-individual variability in the extent of first-pass metabolism, leading to unpredictable plasma concentrations and responses after oral administration

Antioxidants in turmeric may alsoreduce therisk ofcataracts, glaucoma and macular degeneration

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These DAMPs activate the innate immune system, particularly Kupffer cells (liver-resident macrophages) and recruited monocytes, which release proinflammatory cytokines like TNF-, IL-1, and IL-6