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Cortisol and its analogs are therefore used pharmacologically as immunosuppressants after transplant operations and in the treatment of severe skin allergies and autoimmune diseases, such as rheumatoid arthritis

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Gut microbiota promotes granulocyte-macrophage colony-stimulating factor (GM-CSF) production, which activates extracellular signal-regulated kinase signaling in alveolar macrophages to enhance airway defenses (Brown et al., 2017)

High-fat diets, for example, have been shown to increase plasma acylcarnitine levels, and this effect is partly mediated by alterations in gut microbial metabolism [177]