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What are the two important byproducts of the HMP shunt

The triple amino acid mutation at M252Y/S254T/T256E (the YTE modification) was shown to promote a fourfold increase in serum half-life of mAbs due to increased binding to FcRn 84 , and was used in tixagevimab and cilgavimab on top of the TM modification (see above) to extend their half-life 76

To combat this, the use of induced pluripotent cells from the affected individuals to deduce the metabolic fate of compounds could also be seen as a potential option in future

Ren, W., Liu, Y., Wang, X., Jia, L., Piao, C., Lan, F., & Du, J