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[69] In mice [70] and in rats [71] contextual fear conditioning, within 124 hours, it is associated with altered methylations of several thousand DNA cytosines in genes of hippocampus neurons

The Notch pathway inhibitor stapled alpha-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma

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Results Across mechanistic endpoints, LC was associated with reductions in inflammatory markers, oxidative stress indices, and cardiac injury biomarkers, with several trials noting improvements in left-ventricular function and lipid profiles

10.1186/s12933-019-0879-0 Summary Keywords mitoepigenetics, mtDNA, ncRNAs, mitochondria, aging, cardiovascular diseases, methylation Citation Mongelli A, Mengozzi A, Geiger M, Gorica E, Mohammed SA, Paneni F, Ruschitzka F and Costantino S (2023) Mitochondrial epigenetics in aging and cardiovascular diseases